RIKEN team finds genetic deletion that suppresses amyloid ß production in mice

A group around Kenichi NAGATA Generation has used an knock-in mouse model carrying a humanized Aβ sequence and edited the genome of the model zygotes using multiple combinations of CRISPR/Cas9 tools produces genetically mosaic animals with various App 3′-UTR deletions. An App knock-in mouse with a 34-bp deletion in a 52-bp regulatory element adjacent to the stop codon showed a substantial reduction in Aβ pathology, suggesting gene therapy as a putative future procedure to suppress amyloid ß production.

Source: RIKEN news release, May 4, 2018

Request a quote for deeper information from
contact@asia-tech.eu

© 2018 Window to Japan - Bio 4 Business - Imprint